Apid Report Hronic Behavioral Stress Induces Apical Dendritic Eorganization in Pyramidal Neurons of the Medial Refrontal Cortex
نویسنده
چکیده
bstract—Both the hippocampus and the medial prefrontal ortex (mPFC) play an important role in the negative feedack regulation of hypothalamic–pituitary–adrenal (HPA) acivity during physiologic and behavioral stress. Moreover, hronic behavioral stress is known to affect the morphology f CA3c pyramidal neurons in the rat, by reducing total ranch number and length of apical dendrites. In the present tudy, we investigated the effects of behavioral stress on the PFC, using the repeated restraint stress paradigm. Animals ere perfused after 21 days of daily restraint, and intracelluar iontophoretic injections of Lucifer Yellow were carried out n pyramidal neurons of layer II/III of the anterior cingulate ortex and prelimbic area. Cellular reconstructions were perormed on apical and basal dendrites of pyramidal neurons in ayer II/III of the anterior cingulate and prelimbic cortices. We bserved a significant reduction on the total length (20%) and ranch numbers (17%) of apical dendrites, and no significant eduction in basal dendrites. These cellular changes may mpair the capacity of the mPFC to suppress the response of he HPA axis to stress, and offer an experimental model of tress-induced neocortical reorganization that may provide a tructural basis for the cognitive impairments observed in ost-traumatic stress disorder. © 2004 IBRO. Published by lsevier Ltd. All rights reserved.
منابع مشابه
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex.
The prefrontal cortex (PFC) plays an important role in higher cognitive processes, and in the regulation of stress-induced hypothalamic-pituitary-adrenal (HPA) activity. Here we examined the effect of repeated restraint stress on dendritic spine number in the medial PFC. Rats were perfused after receiving 21 days of daily restraint stress, and intracellular iontophoretic injections of Lucifer Y...
متن کاملChronic stress alters dendritic morphology in rat medial prefrontal cortex.
Chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. Medial prefrontal cortex is a target for glucocorticoids involved in the stress response. We have previously demonstrated that 3 weeks of daily corticosterone injections result in dendritic reorganization in pyramidal neurons in layer II-III of medial prefrontal cortex. To determine if s...
متن کاملDendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration.
Chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. For example, both stress and chronic administration of corticosterone produce dendritic atrophy in hippocampal neurons (Woolley C, Gould E, McEwen BS. 1990. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res 531:225-231; Watan...
متن کاملMild, short-term stress alters dendritic morphology in rat medial prefrontal cortex.
Prefrontal cortex is a target for glucocorticoids, shows neurochemical changes in response to stress and mediates many of the behaviors that are altered by chronic corticosterone administration. Three weeks of either daily corticosterone injections or 3 h daily restraint stress result in dendritic changes in pyramidal neurons in medial prefrontal cortex. Interestingly, vehicle injection results...
متن کاملSpecific configuration of dendritic degeneration in pyramidal neurons of the medial prefrontal cortex induced by differing corticosteroid regimens.
We previously demonstrated that hypercorticalism induces pronounced volumetric reductions in the rat medial prefrontal cortex (mPFC) and that these structural changes correlate with deficits in executive function. By applying 3-dimensional analysis of Golgi-Cox-stained material, we now demonstrate that corticosteroids can exert differential effects on dendritic arborizations of pyramidal neuron...
متن کامل